Disadvantages of ED treatment

Drugs:

  • Sildenafil
    Onset of action Tmax* 30–120minutes. Median 60 minutes
    Half life 2–5 hours
    Adverse effects • Headache• Flushing• Dyspepsia
  • Vardenafil
    Onset of action Tmax 30–120 minutes Median 60 minutes
    Half life 4.5 hours
    Adverse effects• Headache• Flushing• Dyspepsia
  • Tadalafil
    Onset of action Tmax 30–120 minutes Median 120 minutes
    Half life 15.5 hours
    Adverse effects• Headache• Flushing• Dyspepsia

* Tmax = median time to peak plasma concentration of drug

Vacuum erection devices

Disadvantage
Bruising
Interference of ejaculation due to constriction ring
Loss of acute angle of erection
Pain
‘Nonphysiological’ erection
Requires the use of bulky equipment

Contraindications
Bleeding disorders
Anticoagulation therapy

Intracavernosal injections

Disadvantages
Risk of priapism
Painful erections
Tolerance
Urethral bleeding
Hypotension
Low compliance rates

Contraindication
Conditions that predispose to priapism
Sickle cell anaemia
Leukaemia

For more information about drugs for erectile dysfunction treatment click here